Human disease info

Diabetes that is secondary to an identifiable condition is comparatively rare. For example, de­struction of the pancreas secondary to pancreatitis will impair insulin secretion and result in dia­betes. In certain endocrine disorders such as Cushing’s syndrome, acromegaly, pheochromo-cytoma, and glucagonoma, the increased secre­tion of hormones that counteract the effect of in­sulin can also result in hyperglycemia. By a variety of mechanisms, a number of commonly used drugs such as diuretics, corticosteroids, pro­pranolol, phenytoin, and adrenergic agents also cause or exacerbate diabetes.
Acanthosis nigricans may be associated with se­vere insulin resistance, resulting in diabetes by two distinct mechanisms: (1) Type A—the insulin resistance is due to a marked decrease in the num­ber of cellular insulin receptors. These patients are usually young females with hirsutism and po­lycystic ovaries. (2) Type B—the insulin resist­ance is due to autoantibodies against the insulin receptor as part of a more generalized autoim­mune process manifested by proteinuria, leuko­penia, and antinuclear antibodies.

Tags: adrenergic agents, antinuclear antibodies, betes, cushing s syndrome, cytoma, distinct mechanisms, endocrine disorders, hirsutism, hyperglycemia, insulin receptor, insulin receptors, insulin resistance, insulin secretion, num ber, penia, phenytoin

• DIABETES MELLITUS - DIAGNOSIS
• Yeminli Dictionary "Millions of Pretranslated English Turkish Sentences"
• DIABETES MELLITUS - Secondary Diabetes
• CLASSIFICATION OF DIABETES
• PRIMARY HYPOGONADISM
• GYNECOMASTIA
• SECONDARY HYPOGONADISM
• IMPOTENCE
• CRYPTORCHIDISM
• DIABETES MELLITUS - Type II Non-Insulin-dependent Diabetes Mellitus (NIDDM)
• DIABETES MELLITUS